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Improving the Efficacy of Capsinoids as a Thermogenic Adjunct in Clinical Weight Management
New research over the last five years is clarifying the mechanisms by which capsinoids – thermogenic compounds in certain strains of chili peppers – can
regulate fat metabolism and help over-weight individuals reduce abdominal fat and improve their health. Application of the new findings to the formulation of capsinoid-based products holds great potential to improve results obtained with this emerging adjunctive modality.
Capsinoids are non-stimulant compounds that increase basal metabolism and fat oxidation, helping people overcome one of the biggest physiological
barriers to weight control: the metabolic suppression that follows prolonged calorie restriction. Unlike capsaicin, the more widely known biochemical constituent of chili peppers, capsinoids are not absorbed systemically; they have much less pungency, do not cause any burning sensation, and have no effects on the
cardiovascular function, giving them significant advantages for clinical use. Recent work indicates that at a dose of 9 mg/day, capsinoids also increase
the amount and the activity of brown adipose tissue (BAT), an important regulator of overall body fat content. Age-associated loss of BAT and diminution
of BAT activity correlate strongly with an accumulation of total body fat and with weight gain (Yoneshiro T, et al. Obesity. 2011; 19(9): 1755-1760).
Recruitment and reactivation of BAT represent a new and largely untapped mechanism for weight management. Physiology of Weight Gain to improve weight management outcomes It is important to understand that for many people physiology itself can become a major stumbling block to Basal metabolic rate (BMR). BMR is the main determinant of daily energy expenditure. It drops by as much as 2% per decade after the age of 20. The changes are due in part by declining thyroid function, loss of lean muscle mass, and reduced metabolic activity in lean tissue. If caloric input remains constant or increases as someone ages, the stage is set for weight gain, even in people who were lean in youth. Weight gain may reflect a genetic predisposition to low resting metabolic rate (RMR), a measurement that is well-correlated with BMR.
Calorie Restriction & Metabolic Down-Regulation
The heavier a person is, the heavier he or she tends to become. The problem is compounded by the fact that calorie restriction suppresses BMR.
Very low-calorie diets may end up giving the opposite of their intended effect. Calorie restriction induces a down-regulation of metabolic rate.
The Role of Brown Adipose Tissue Over the last decade
Researchers have shed considerable light on the role of Brown Adipose Tissue (BAT) in fat metabolism and energy balance. BAT burns fat to produce heat when the body is exposed to cold and plays an important part in regulating total energy expenditure. People with undetectable BAT activity are more likely to have an increase in body fat with age. Those with detectable BAT activity show total fat content as unchanged from the 20s to the 40s, which suggests that the age-related decrease in BAT activity accelerates the accumulation of body fat. Capsinoids can increase the amount and activity of BAT tissue and therefore decrease body fat composition.
If you want to kick-start your weight loss program consider adding this thermogenic supercharger.