Regenerative Medicine: PRP (Platelet-Rich Plasma)

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What is Regenerative Medicine?  Regenerative medicine is the sub-branch of medicine aimed at regenerating tissues and promoting new blood flow with the use of non-autologous and autologous substances.  PRP (platelet-rich plasma) can be defined as a volume of autologous plasma with the platelet concentration above baseline. PRP has been clinically applied for its healing properties, and now is widely applied in many therapeutic areas.  Platelets can secrete a variety of growth factors, including PDGF, IGF-1, TGF-β, VEGF, bFGF, EGF, and CTGF*, among others. All these growth factors play significant roles in promoting the proliferation of tissues and angiogenesis. Platelets also contain antibacterial and bactericidal proteins that may influence the process of inflammatory responses by inducing the synthesis of some molecules, such as integrins, interleukins and chemokines. Last but not least, platelets may serve as a biological sponge because they can absorb, store and transfer some small molecules that regulate tissue regeneration. PRP represents a new biotechnology in tissue engineering and has become a popular clinical treatment for various tissue healing applications without any immune rejections.

How can you obtain PRP?  PRP is obtained by taking a volume of blood and concentrating the platelets with the use of a centrifuge. The platelet-rich plasma layer is then extracted from the red blood cells.  These platelets can then be injected into the tissues of interest.

  • PDGF: Platelet Derived Growth Factor, IGF-1: Insuliin-Like Growth Factor-1,TGF-β: Transforming Growth Factor Beta-1, VEGF: Vascular Endothelial Growth Factor,bFGF: Basic-fibroblastic Growth Factor,EGF: Epidermal Growth Factor,CTGF: Connective Tissue Growth Factor