Why Testosterone Deficiency Causes Muscle Loss, Frailty, Cognitive Decline and Aging

Testosterone Deficiency Syndrome

Testosterone Deficiency Syndrome

Many Scientists are focused on microscopic chemical changes in cells as they relate to aging, but they fail to give proper weight to the loss of a major hormone associated with aging that triggers the small chemical changes that cause aging in men and women. For example, a myopic focus on chromosomal telomere lengths and taking supplements to extend telomere lengths may be of little benefit to the overall health of an individual if the individual does not have proper testosterone levels. But Why?


Inflammation: The First Change

Testosterone is a major anti-inflammatory and anabolic hormone in the human body. The large decrease in testosterone levels in our 40s and


50s represents the first major hormone to fall in the aging cascade.   The first change in aging is increased inflammation. Increased inflammation around our organs and tissues leads to high blood pressure, stroke, arthritis, heart disease and muscular pains. Inflammation is a powerful catalyst in the aging process.

Testosterone Deficiency Syndrome: Why Can’t I Think

Loss of testosterone also causes muscles to shrink and bones to dissolve by diverting blood flow to these tissues thereby, greatly suppressing anabolic growth and muscle repair.  The muscles in our body have a direct effect on the brain by the secretion of a compound called BDNF, brain-derived neurotrophic factor. Without proper muscle bulk and muscle activity, we gradually lose our ability to think. In short, without your muscles — you literally lose your ability to think!  Clearly, we need to keep our muscles active with some form of strength training whether we are a man or woman.

Testosterone Replacement

Testosterone Deficiency Syndrome–>Loss of Muscle —> Immobility —>Obesity—>Type 2 DM

As we progress down the aging cascade, we see that loss of testosterone causes inflammation and loss of muscle mass. Loss of muscle mass results in loss of mobility and increased immobility. This dangerous spiral leads to frailty. The immobility that is associated with muscle loss causes us to become obese and this, in turn, raises our BMI.  An increase in our BMI next results in the development of insulin resistance and type 2 diabetes.  Type 2 diabetes is fast becoming the number of the enemy in America and around the world. The disease now affects about one-third of Americans and costs billions of dollars to manage and treat.

Testosterone Replacement

Testosterone replacement is a pivotal early step that can help to intervene in the aging cascade. This one hormone has the potential to prevent several adverse symptoms related to the development of diabetes and the aging cascade.



Talk to your hormone specialist about getting your testosterone levels checked today! BioFunctionalMed 919.926.9575

Bio-FunctionalMed 919.926.9575



  1. […] many doctors are not familiar with the new wave of bio-identical treatments available to help the aging population.  Additionally, because of bad outcomes related to synthetic hormone use many physicians are […]

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